NStride is a cutting-edge treatment designed for the management of osteoarthritis (OA), a degenerative joint condition characterised by the breakdown of cartilage, leading to pain, stiffness, and reduced mobility. NStride has garnered attention as a promising alternative to conventional treatments such as pain relievers, corticosteroid injections, or joint replacement surgery. By leveraging the body’s natural healing mechanisms, NStride seeks to address the underlying causes of osteoarthritis rather than merely managing its symptoms.
Indications for NStride Treatment
NStride is primarily indicated for patients suffering from mild to moderate osteoarthritis of the knee. It is especially suitable for those who have not responded adequately to other conservative treatments such as physiotherapy, oral anti-inflammatory medications, or hyaluronic acid injections. While its use is primarily focused on knee OA, emerging studies suggest potential benefits for other weight-bearing joints like the hip and ankle.
Physiology of Action and Mechanism
Osteoarthritis is marked by chronic inflammation and the progressive degradation of cartilage, driven by an imbalance between pro-inflammatory and anti-inflammatory mediators in the joint. In particular, cytokines such as interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-α) play a pivotal role in promoting inflammation and cartilage destruction.
NStride works by counteracting these destructive processes. It is an autologous therapy, meaning it utilises the patient’s own blood to create a concentrated solution rich in anti-inflammatory proteins, growth factors, and platelets. A key component is the IL-1 receptor antagonist (IL-1Ra), which binds to IL-1 receptors in the joint, effectively blocking the inflammatory cascade and slowing cartilage breakdown. Additionally, the growth factors in the solution help stimulate tissue repair and regeneration, offering a dual-action approach to treatment.
nStride Procedure
The NStride procedure is minimally invasive and typically performed in an outpatient setting. It involves two primary steps:
- Blood Collection: A small amount of the patient’s blood (approximately 50 mL) is drawn from a vein, similar to a routine blood test.
- Processing: The blood is processed using a centrifuge system to isolate a concentrated serum containing high levels of anti-inflammatory proteins and growth factors. The entire preparation takes about 20-30 minutes.
- Injection: The prepared serum is injected directly into the affected joint under ultrasound guidance to ensure precision.
The procedure is generally well-tolerated, and most patients can return to their normal activities shortly afterwards.
Evidence of Effectiveness
Clinical studies have demonstrated the efficacy of NStride in reducing pain and improving joint function in patients with knee osteoarthritis. Research indicates that a single injection can provide symptom relief for up to 24-36 months.. A 2017 study published in The American Journal of Sports Medicine found that patients who received NStride experienced significant reductions in pain and improvements in quality of life compared to those treated with placebo injections.
In addition to clinical trials, real-world evidence supports NStride’s benefits. Patients often report reduced reliance on pain medications and greater ability to engage in physical activity following treatment.
What to Expect
Patients can expect a relatively quick procedure with minimal discomfort. Post-injection, some individuals may experience mild swelling or soreness at the injection site, but these symptoms usually subside within a few days. The full therapeutic effects may take several weeks to become apparent as the anti-inflammatory proteins modulate joint inflammation and promote healing.
For many, NStride offers a significant improvement in pain and function, enabling a more active lifestyle. However, as with any medical intervention, results can vary depending on the severity of osteoarthritis and individual patient factors. Regular follow-ups with the healthcare provider are recommended to monitor progress and determine whether additional treatments are needed.
In summary, NStride represents a novel, biologically based approach to treating osteoarthritis. By addressing the inflammatory processes underlying the condition and supporting cartilage health, it offers hope for long-term symptom relief and improved joint function. For suitable patients, NStride provides an effective, minimally invasive alternative to more invasive interventions.
Frequently Asked Questions (FAQs) about NStride APS Treatment
NStride APS (Autologous Protein Solution) is an advanced regenerative therapy used to treat joint pain and inflammation, particularly in conditions like osteoarthritis. The treatment involves extracting a small amount of your own blood, processing it to concentrate the healing proteins, and then injecting it back into the affected joint to promote healing and reduce pain.
NStride APS works by harnessing the body’s own natural healing properties. The treatment concentrates platelets and growth factors found in the blood, which are then injected into the damaged joint. These components stimulate tissue repair, reduce inflammation, and help to regenerate cartilage, potentially improving joint function and reducing pain.
NStride APS is generally recommended for individuals with joint pain, particularly due to osteoarthritis or injury. However, it may not be suitable for individuals with certain health conditions, such as blood disorders or infections. A thorough consultation with a healthcare provider is required to determine if NStride APS is right for you.
The potential benefits of NStride APS include:
Reduced joint pain and inflammation
Improved joint mobility and function
Stimulated cartilage repair and tissue regeneration
A non-surgical alternative to other treatments such as steroid injections or joint replacement
The procedure begins with a blood draw, typically from the arm, which is processed to concentrate platelets and growth factors. Once prepared, the solution is injected directly into the affected joint under local anaesthesia. The process usually takes around 30 to 60 minutes, and you may be able to return to your normal activities shortly after, although some rest is recommended.
Most patients typically receive one or two injections per treatment cycle, though the number of treatments can vary based on the severity of the condition. Some patients may experience significant improvement after just one treatment, while others may require follow-up injections after a few months.
Recovery time is usually minimal, with most patients able to return to normal activities within a day or two. However, mild soreness, swelling, or bruising at the injection site is common for a few days. It’s advisable to avoid strenuous activities for a short period post-treatment to allow for optimal healing.
NStride APS is generally considered safe because it uses your own blood, reducing the risk of allergic reactions or infection. However, as with any injection, there may be temporary side effects such as mild pain, swelling, or bruising at the injection site. In rare cases, infections or other complications may occur, but these are uncommon.
Many patients begin to feel relief within a few weeks to a few months after treatment, although the full benefits may take several months to develop. The treatment works gradually as the healing proteins stimulate tissue repair and reduce inflammation over time.
NStride APS is often used in conjunction with other non-invasive treatments, such as physical therapy or lifestyle changes, to enhance results. However, it’s important to consult with your doctor to ensure there are no conflicts or risks when combining therapies.
The effects of NStride APS can vary from patient to patient, but many experience long-lasting relief for 12-36 months. Some individuals may need additional treatments after this period to maintain the benefits
Ideal candidates are those with moderate to severe joint pain, particularly in the knees, shoulders, or hips, due to mild to moderate osteoarthritis or injury. Individuals who have not responded well to other conservative treatments such as physical therapy, pain medications, or corticosteroid injections may benefit from NStride APS
For one joint, the cost is £1800, which is fully inclusive of consultation, X-ray (if required), procedure and follow up appointment.